2021.07.24 18:54 PutridActuator2 仍仍 BBY DOGE - CURRENTLY 100K MC - THIS IS MOONSHOT OF THE YEAR!

仍仍 BBY DOGE 仍仍 Get in Before The DOGE Pump! LOCKED LIQUIDITY - 50-100X GEM! Low Market Cap
Meme coin on steroids! Perfect time to get in. Lets get Elon to tweet about us!
儭 80% Burned from total supply. 儭 Ownership Renounced!
We want to provide maximum transparency for maximum security. The crypto-space is full of scams. We are here to give you a safe and secure investment instrument.
Contract address: 0xe1bca00bdc01affa3c2b41c835dc57588c01f4b9
仍Chart: https://charts.bogged.finance/0xe1bca00bdc01affa3c2b41c835dc57588c01f4b9
儭儭Holders: Less than 100 currently
儭Marketcap: Less than 30K USD
仍Pancakeswap: https://exchange.pancakeswap.finance/#/swap?outputCurrency=0xe1bca00bdc01affa3c2b41c835dc57588c01f4b9
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2021.07.24 18:54 AluminiumGnat Watame Shogun

Watame Shogun submitted by AluminiumGnat to Tsunomaki_Watame [link] [comments]

2021.07.24 18:54 reydai Very interesting

Very interesting submitted by reydai to systemzee [link] [comments]

2021.07.24 18:54 JBPrimtal mushroom house! fan art for @pale_sunshine_pie on tiktok

mushroom house! fan art for @pale_sunshine_pie on tiktok submitted by JBPrimtal to MagicaVoxel [link] [comments]

2021.07.24 18:54 yellowmedia12321 One week post op from lapidus bunionectomy with osteotomy for tailors bunion

One week post op from lapidus bunionectomy with osteotomy for tailors bunion submitted by yellowmedia12321 to bunions [link] [comments]

2021.07.24 18:54 Shupap11

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2021.07.24 18:54 acaiberishu City from above.

City from above. submitted by acaiberishu to Cyberpunk [link] [comments]

2021.07.24 18:54 ManUtdUpdates_ More Game Time For The Young Lads

More Game Time For The Young Lads submitted by ManUtdUpdates_ to ManchesterUnited [link] [comments]

2021.07.24 18:54 APThompson1 New Momentum Ts Sizing

New Momentum Ts Sizing submitted by APThompson1 to Athleta_gap [link] [comments]

2021.07.24 18:54 DragonShine Whre do I find normal Gravios egg in mhs2?

Ive been searching in Tegra but all I can find is the black one. Can anyone tell me which rare dens i need to look in or which gravios to paintball?
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2021.07.24 18:53 lurker_bee Microsoft predicts over 40% of people may quit their jobs this year

Microsoft predicts over 40% of people may quit their jobs this year submitted by lurker_bee to economy [link] [comments]

2021.07.24 18:53 SSandStuff #fitgirls

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2021.07.24 18:53 Adronikos JAANGO FEETTTTTTT!!!!!

JAANGO FEETTTTTTT!!!!! submitted by Adronikos to PrequelMemes [link] [comments]

2021.07.24 18:53 FrontpageWatch2020 [#109|+2264|108] Adding Road Lettering [r/specializedtools]

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2021.07.24 18:53 Sidelingpit2 17M Im just looking for friends

Hello im a 17 year old male that love video games and anime and I guess you would call it folklore and urban legends and I would love to talk to someone who isnt family. You can fm me here or on discord which is Sidelingpit2635#8423
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2021.07.24 18:53 VegetableConstant240

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2021.07.24 18:53 julzzzz_ i got this rock today but idk its name, any ideas???

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2021.07.24 18:53 FrontpageWatch2020 [#276|+2619|56] Insane candy cutting [r/woahdude]

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2021.07.24 18:53 Dandelion_Guy Kodak ColorPlus 200;意ikon F-801S+Nikkor 50mm f1.4D

Kodak ColorPlus 200;意ikon F-801S+Nikkor 50mm f1.4D submitted by Dandelion_Guy to CatsOnFilm [link] [comments]

2021.07.24 18:53 DAALyt_YouTube plssss remove system points cap bc I have baros 3 with expert and I don't want to get points so slow slow slow.......

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2021.07.24 18:53 ieatpencils1 Rosacea since birth?

Ive had rosy cheeks for as long as i can remember, after doing some research I found out rosacea is apparently really rare in children. I have pictures from when i was 12 (17 now) and it was just as bad back then, if not worse. Im just trying to figure out if its rosacea or not, could i have just been born with naturally rosy cheeks? Mines doesnt really look like rosacea, the redness isnt blotchy, and I dont have acne around it, its just smooth and pink. Appreciate any opinions.
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2021.07.24 18:53 BurkeAbroad Hangover Preventative Formula - costs about 70 cents for you to make yourself

I mentioned this formula in a couple of comments on other posts and figured this would probably be the best way to share with everyone.
First things first. Here's the formulation...

Ingredient Dose (mg) Notes
Acetyl-L-Carnitine (ALCAR) 1000
Agmatine Sulfate (AS) 1000
Trimethylglycine 1000 Betaine Anhydrous, not Betaine HCl
Curcumin 1000 Phytosome preferred
Dihydromyricetin (DHM) 1000 Beta-cyclodextrin complex preferred
Milk Thistle 500 Phytosome preferred
Boswellia 500 Phytosome preferred
Glycine 1000
L-Theanine 200
N-AcetylCysteine (NAC) 1000 Can also use L-Cysteine / N-acetylcysteine amide
Taurine 500
Nicotinamide Mononucleotide (NMN) 500
Tyrosine 500

Next, I apologize in advance for the weird formatting. Shit saved differently than I had it, and it's like dealing with old school Microsoft word. Painful.
Now then, this formulation can be taken before or after drinking. NAC had one study showing that it increased damage to the liver if taken after intoxication. It was in one study. Literally one, and not a very good / complete one at that. However, I'm not a fucking doctor, so make your own informed choices. I can send the research papers I used for NAC specifically, as well. I have taken this formulation before drinking and after drinking, and it works incredibly well. It has also worked incredibly well for the friends I have shared it with. Literally, every single person has told me this has dramatically reduced their hangovers mentally and physically. From my testing, this formulation is good for about 6 to 8 drinks for a 180lb male. You may have to experiment to get your dosing right for your own body.
This is a conglomeration of interviews I took from folks who tried it. When taken before drinking, you may notice that you do not get drunk in the same way as you would expect. For starters, you hardly notice the physical effects. You feel the buzz you get after the first drink or two, and it stays with you for the night. You just feel very calm and in control of yourself, more social and outgoing. Just comfortable. You also don't 'need' a drink in your hand at all times. The anxiety to have another is not nearly as strong.
If taken after, you can toss this in your mouth and wash it down with your beverage of choice. If using the phytosome and betacyclodextrin complexes, the mixture will be relatively water soluble. I threw it in a workout mixer thing with water and downed it. The taste isn't awful but could be better. A bit of juice makes it hardly noticeable.
There you have it. Here's what I'll cover in the next two parts of this post:

  1. Research behind this - effects of alcohol, how these ingredients counteract or help these effects, and other ingredients that could also be included. General summaries of each ingredient above + other ingredients I opted not to include.
  2. A bit of background about why I made this. I'll avoid talking about any business stuff, as I don't want this to be taken as an astroturfing post.
The Research: We are going to start with booze and how your body deals with it. This is the basic metabolism process that needs to be understood. There are major offshoots not covered in this, but not terribly important.

Alcohol Metabolism
Now, within this metabolism process the major culprit of most damage to the body and brain is with acetaldehyde. Acetaldehyde is a **very** reactive oxygen species (ROS) and has been linked to almost every negative effect you can imagine from face flushing to crippling addiction. Within this metabolism process, the conversion of ethanol to acetaldehyde is relatively quick (Enzyme - Alcohol Dehydrogenase - ADH), while the conversion of acetaldehyde to acetate (Enzyme - Alcohol Dehydrogenase - ALDH) is much slower. Acetate isn't as big of a problem and tends to be cleared in step with concentrations of taurine - more on that later.
You may have heard of the Asian Glow. It refers not just to your homie that has one beer and loses it entirely, but mainly to a genetic mutation in the ALDH II enzyme that greatly reduces its activity. In short, people with this mutation build up acetaldehyde way quicker than someone without. This causes them to suffer worse hangovers from seemingly inconsequential amounts of alcohol as well as many other fun effects that you tend to only get from really hitting the sauce hard.
But wait, there's more!
Your body, being the insanely adaptive piece of genius that it is will tend to get better and better at processing alcohol - usually at the expense of other processes. Your friends that drink every weekend into oblivion probably have an easier time getting over a hangover than the guy or gal that only drinks a few times or once in a blue moon. Or put more succinctly "Hangovers are substantially more common in light-to-moderate drinkers than in heavier drinkers - possibly because the body hasnt adapted to chronic alcohol injury. "
Here's another couple tidbits I found interesting from my research: hangover severity is inversely correlated to testosterone levels. This may be the reason that hangovers get progressively worse as we get older, as our hormone levels naturally level off and begin to drop. Oddly enough, testosterone levels will go up while drinking, but crash, with an increase in estrogen, once your BAC drops.
Acetaldehyde has been shown to be 10 to 1000x more addictive in terms of dopamine release than ethanol in multiple animal models. People aren't alcoholics, they are acetaldehydics or however that term would end up.
Here are the overall categories of effects from alcohol:
  1. ROS and RNS damage - inflammation, neuroinflammation, lipid peroxidation.
  2. The antioxidant enzyme, cofactor, and substrate depletion.
  3. Mitochondrial damage + dysfunction
  4. Endocrine system hormonal system out of wack (Lower T, Higher E)
  5. Neurotransmitter dysfunction (GABA, Glutamate, Dopamine, Serotonin, Acetylcholine)
  6. Decrease in insulin sensitivity (like diabetes) - metabolism
  7. Sleep Cycle disruption
  8. Immune system suppression
If we were to summarize this... A hangover is like having a temporary bout of anxiety, diabetes, and Alzheimers.
Major physical effects - low energy, fucked up metabolism, skin break outs, etc. tend to be caused by the exhaustion of antioxidant enzymes. Your body prioritizes using them to clear alcohol and all its metabolites that tend to react with acetaldehyde at the expense of essentially every other process that keeps you feeling good.
Major mental effects - anxiety, wanting to do stuff that gives you a quick dopamine boost like eating shit food or watching (adult) cartoons all day, having zero motivation. These are all neurochemical imbalances. The largest is GABA/Glutamate balance getting fucked up. When you drink, GABA goes up and glutamate goes down. This gives you a feeling of relaxation and ease. Arguably why you find it easier to speak to crowds of folks if you'd normally be shitting yourself nervous. During withdrawal / hangovers, this is reversed. GABA goes down, glutamate goes up. It makes you hypersensitive and anxious. It is hard to focus because everything draws your focus. Withdrawal starts the moment your BAC starts dropping. Yes, so literally after the first drink. And it will get worse as you keep going. On top of this, your normal feel-good neurotransmitters - dopamine, serotonin, acetylcholine - get depleted. So you wake up after boozing, and you're running low on happiness or whatever the chemical equivalent is. Guh. These imbalances will also make it difficult to sleep the night of drinking and even a night or two after.
For major alcoholics, the above anxiety can be absolutely crippling. And... alcohol delivers instant GABA boost which is then dopamine reinforced. Brutal. Your brain will actually start to produce less GABA as you slide into alcoholism, making it extremely difficult to get rid of this anxiety after drinking.
Supplements: I'll start with summaries on the ones I included, then give a brief summary of others that help the categories above. Feel free to shoot me a DM or leave a comment if you want a breakdown of an individual supplement that I mention but was not given a detailed description.
The primary focus of this mix is to speed up the clearance of acetaldehyde, to reinforce/protect/regenerate/enhance the antioxidant enzymes to lessen oxidative damage, and finally to get the brain's neurochemistry back into balance to lessen the chances of addictive behavior patterns and relieve the anxiety and fucked up mental state a hangovewithdrawal brings with it.
I made this formula to protect against as much harm using the fewest number of ingredients possible. At the end of this list is a summary that includes other ingredients I researched, and categorically where they could also help. Feel free to ask for summaries on them. For instance, passion flower naturally increases Testosterone and is awesome for anti-addictive behaviors.
Acetyl-L-Carnitine (ALC) - Protects antioxidant enzymes, stabilizes neurotransmission, and protects mitochondria - the power house of the cell. May help you sleep too.
Agmatine Sulfate (AS) - Helps with glutamate toxicity. Glutamate
Trimethylglycine - Betaine - Liver protective, accelerated clearance of acetaldehyde.
Dihydromyricetin (DHM) - acetaldehyde clearance, GABA/Glutamate neurochemistry balance.
Milk Thistle - Silymarin - oxidative stress protection, liver protection, antioxidant enzyme restoration.
Boswellia - Oxidative stress protective, reset metabolism.
Glycine - neurotransmitter regulation - specific GABA/Glutamate
L - Theanine - Neurotransmitter regulation - specific GABA/Glutamate
N-Acetyl-Cysteine (NAC) - Reducing oxidative damage and regulating/protecting proper neurochemistry.
Taurine - N-Acetyl-Taurine (NAT) - clearing acetate and speeding up clearance of acetaldehyde.
Nicotinamide Mononucleotide (NMN) - Nicotinamide Riboside and Ubiquinone are very similar - speeding up metabolism of acetaldehyde and regenerating antioxidant enzymes.
Tyrosine - restoring neurotransmitters
Notes on Supplements: Plant extracts tend to have a major problem. Bioavailability. For example, milk thistle is less than 1% bioavailable. Recently, advances have been made to increase bioavailability with encapsulation methods - most notably the phytosome and liposomal encapsulation techniques - or including other ingredients that increase bioavailability - like black pepper (bioperine) for curcumin.
In my ingredients, I mention betacyclodextrin and phytosomes. These are two encapsulation methods that increase bioavailability about 5 to 10x. They also make the extracts more dissolvable in water. Indena is THE major seller of phytosomal complexes - they got patents - and they sell to multiple retailers. If you type phytosome curcumin in Amazon, you'll find them. Another source is botany.bio
Everything else mentioned can be found on Amazon in bulk powder with great quality and on the cheap.
Summary of Effects and Other Supplements Researched :
ROS and RNS damage - inflammation, neuroinflammation, lipid peroxidation.
Antioxidant enzyme, cofactor, and substrate depletion.
Mitochondrial damage + dysfunction
Endocrine system hormonal systems out of whack
Neurotransmitter dysfunction (GABA, Glutamate, Dopamine, Serotonin, Acetylcholine)
Decrease in insulin sensitivity (like diabetes) - metabolism
Sleep Cycle disruption - histone acetylation disruption, circadian rhythm.
Microbiome damage
About Me and Whatever:
During this awesome pandemic, I found myself unemployed after selling a previous company. It was at this time that my father started just randomly blacking out when he got up too quickly. To make a long story short, he went to a doc - and doc told him you need to stop drinking. Soon after my mom caught him sneaking swigs in the garage. He finally admitted he'd been an alcoholic for 30 years, basically sneaking off to drink without anybody knowing. Great.
With time on my hands and a bit of anger, I decided to jump back onto this project. I didn't want other people to end up like my dad. From my research, I quickly found that hangovers are a form of withdrawal. The primary cause of alcoholism is from the GABA/Glutamate imbalance during withdrawal that makes it oh so easy to drink more and more.
I blasted through about 400 or so research papers to dig into natural supplements available to remedy as many of the effects of alcohol I could find. I presented my findings to my dad, and he was pretty blown away. Not because it was a magical cure, but because the main thesis was something he had already heard. As it turns out, about a week before I shared all my research and the initial formulation of 40 something supplements, he had found a new age clinic that had repurposed GABA regulating pharmaceuticals to combat alcoholism - with astonishing success.
My dad had been running through various programs over these past months with very little to show for it. This pharma treatment that specifically targeted the GABA/Glutamate balance has been working for him. As of today, he's been sober for about 3.5 months.
Alcoholism is a sliding scale. It's not a binary - alcoholic, non-alcoholic thing. And it is specific to each person. It just seems to me, at least from my experience seeing other friends fall off a cliff in this shit, is that it starts slow and can accelerate at such a slow pace that it doesn't even seem like anything has changed. Then you hit an inflection point, maybe caused by something as mundane as losing a girlfriend or job (or being isolated for 6 months in quarantine) and that process speeds up to where you lose control.
So when I've been asked, "won't stopping a hangover make people just drink more." This is a major part of my answer. I also believe that we should take all measures to protect our health - body and mind - if we decide to take substances that we know are harmful. Everyone knows alcohol is essentially poison, so why not make it better?
Of course, this formulation is not for alcoholics. If you have a serious problem, go get help.
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2021.07.24 18:53 Jgarr86 Breathing and Socialism

It should come as no surprise to anyone here, but we've all been breathing air under the Capitalist MoP for a few hundred years now. Can anyone shine some light on how breathing air into/out from your lungs might work under Socialism? It's not like we can cut up air into equal chunks, so it seems like something that should be left up to the free market.
submitted by Jgarr86 to Socialism_101 [link] [comments]

2021.07.24 18:53 lunastrrange Anyone else feel like they woke up in someone else's life when they started treatment?

Everything from before feels like a dream/nightmare, or like past lives or something I didn't participate in. I just feel so different now, finally myself again. The medication made things much clearer to me and I just can shake this feeling that I don't belong here. Like I'm a different person. I still have episodes though it's not like I'm 100%, I just see things so differently now and I don't think I would have done anything the same if I had gotten treatment 15 years ago when I was a teenager.
I guess I'm just really confused and lost right now, but I also feel like I'm coming home to myself. This shit is so overwhelming and I often wish I could go back to being in my own crazy little oblivious world.
Just needed to get that out, it's taken over my brain lately. Thanks for reading :)
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2021.07.24 18:53 FrontpageWatch2020 [#788|+516|6] A Nintendo Classic. [r/nintendo]

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