🤴🤴 BBY DOGE - CURRENTLY 100K MC - THIS IS MOONSHOT OF THE YEAR!
2021.07.24 18:54 PutridActuator2 🤴🤴 BBY DOGE - CURRENTLY 100K MC - THIS IS MOONSHOT OF THE YEAR!
🤴🤴 BBY DOGE 🤴🤴 Get in Before The DOGE Pump! LOCKED LIQUIDITY - 50-100X GEM! 💎 Low Market Cap
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Contract address: 0xe1bca00bdc01affa3c2b41c835dc57588c01f4b9
️✔️Holders: Less than 100 currently✊
✔️Marketcap: Less than 30K USD
submitted by PutridActuator2 to CryptoMarsShots [link] [comments]
2021.07.24 18:54 AluminiumGnat Watame Shogun
2021.07.24 18:54 reydai Very interesting
2021.07.24 18:54 JBPrimtal mushroom house! fan art for @pale_sunshine_pie on tiktok
2021.07.24 18:54 yellowmedia12321 One week post op from lapidus bunionectomy with osteotomy for tailors bunion
2021.07.24 18:54 Shupap11 😈🤌🏻
2021.07.24 18:54 acaiberishu City from above.
2021.07.24 18:54 ManUtdUpdates_ More Game Time For The Young Lads 💪
2021.07.24 18:54 APThompson1 New Momentum T’s Sizing
2021.07.24 18:54 DragonShine Whre do I find normal Gravios egg in mhs2?
Ive been searching in Tegra but all I can find is the black one. Can anyone tell me which rare dens i need to look in or which gravios to paintball?
submitted by DragonShine to MonsterHunterStories [link] [comments]
2021.07.24 18:53 lurker_bee Microsoft predicts over 40% of people may quit their jobs this year
2021.07.24 18:53 SSandStuff #fitgirls
2021.07.24 18:53 Adronikos JAANGO FEETTTTTTT!!!!!
2021.07.24 18:53 FrontpageWatch2020 [#109|+2264|108] Adding Road Lettering [r/specializedtools]
submitted by FrontpageWatch2020 to longtail [link] [comments]
2021.07.24 18:53 Sidelingpit2 17M I’m just looking for friends
Hello im a 17 year old male that love video games and anime and I guess you would call it folklore and urban legends and I would love to talk to someone who isn’t family. You can fm me here or on discord which is Sidelingpit2635#8423
submitted by Sidelingpit2 to MeetNewPeopleHere [link] [comments]
2021.07.24 18:53 VegetableConstant240 😈
2021.07.24 18:53 julzzzz_ i got this rock today but idk it’s name, any ideas???
submitted by julzzzz_ to whatsthisrock [link] [comments]
2021.07.24 18:53 FrontpageWatch2020 [#276|+2619|56] Insane candy cutting [r/woahdude]
submitted by FrontpageWatch2020 to longtail [link] [comments]
2021.07.24 18:53 Dandelion_Guy 🎞Kodak ColorPlus 200;📷Nikon F-801S+Nikkor 50mm f1.4D
2021.07.24 18:53 DAALyt_YouTube plssss remove system points cap bc I have baros 3 with expert and I don't want to get points so slow slow slow.......
submitted by DAALyt_YouTube to Progressbar95 [link] [comments]
2021.07.24 18:53 ieatpencils1 Rosacea since birth?
I’ve had rosy cheeks for as long as i can remember, after doing some research I found out rosacea is apparently really rare in children. I have pictures from when i was 12 (17 now) and it was just as bad back then, if not worse. Im just trying to figure out if it’s rosacea or not, could i have just been born with naturally rosy cheeks? Mines doesn’t really look like rosacea, the redness isn’t blotchy, and I don’t have acne around it, its just smooth and pink. Appreciate any opinions.
submitted by ieatpencils1 to Rosacea [link] [comments]
2021.07.24 18:53 BurkeAbroad Hangover Preventative Formula - costs about 70 cents for you to make yourself
I mentioned this formula in a couple of comments on other posts and figured this would probably be the best way to share with everyone.
First things first. Here's the formulation...
|Ingredient ||Dose (mg) ||Notes |
|Acetyl-L-Carnitine (ALCAR) ||1000 || |
|Agmatine Sulfate (AS) ||1000 || |
|Trimethylglycine ||1000 ||Betaine Anhydrous, not Betaine HCl |
|Curcumin ||1000 ||Phytosome preferred |
|Dihydromyricetin (DHM) ||1000 ||Beta-cyclodextrin complex preferred |
|Milk Thistle ||500 ||Phytosome preferred |
|Boswellia ||500 ||Phytosome preferred |
|Glycine ||1000 || |
|L-Theanine ||200 || |
|N-AcetylCysteine (NAC) ||1000 ||Can also use L-Cysteine / N-acetylcysteine amide |
|Taurine ||500 || |
|Nicotinamide Mononucleotide (NMN) ||500 || |
|Tyrosine ||500 || |
Next, I apologize in advance for the weird formatting. Shit saved differently than I had it, and it's like dealing with old school Microsoft word. Painful.
Now then, this formulation can be taken before or after drinking. NAC had one study showing that it increased damage to the liver if taken after intoxication. It was in one study. Literally one, and not a very good / complete one at that. However, I'm not a fucking doctor, so make your own informed choices. I can send the research papers I used for NAC specifically, as well. I have taken this formulation before drinking and after drinking, and it works incredibly well. It has also worked incredibly well for the friends I have shared it with. Literally, every single person has told me this has dramatically reduced their hangovers mentally and physically. From my testing, this formulation is good for about 6 to 8 drinks for a 180lb male. You may have to experiment to get your dosing right for your own body.
This is a conglomeration of interviews I took from folks who tried it. When taken before drinking, you may notice that you do not get drunk in the same way as you would expect. For starters, you hardly notice the physical effects. You feel the buzz you get after the first drink or two, and it stays with you for the night. You just feel very calm and in control of yourself, more social and outgoing. Just comfortable. You also don't 'need' a drink in your hand at all times. The anxiety to have another is not nearly as strong.
If taken after, you can toss this in your mouth and wash it down with your beverage of choice. If using the phytosome and betacyclodextrin complexes, the mixture will be relatively water soluble. I threw it in a workout mixer thing with water and downed it. The taste isn't awful but could be better. A bit of juice makes it hardly noticeable.
There you have it. Here's what I'll cover in the next two parts of this post:
- Research behind this - effects of alcohol, how these ingredients counteract or help these effects, and other ingredients that could also be included. General summaries of each ingredient above + other ingredients I opted not to include.
- A bit of background about why I made this. I'll avoid talking about any business stuff, as I don't want this to be taken as an astroturfing post.
We are going to start with booze and how your body deals with it. This is the basic metabolism process that needs to be understood. There are major offshoots not covered in this, but not terribly important.
Now, within this metabolism process the major culprit of most damage to the body and brain is with acetaldehyde. Acetaldehyde is a **very** reactive oxygen species (ROS) and has been linked to almost every negative effect you can imagine from face flushing to crippling addiction. Within this metabolism process, the conversion of ethanol to acetaldehyde is relatively quick (Enzyme - Alcohol Dehydrogenase - ADH), while the conversion of acetaldehyde to acetate (Enzyme - Alcohol Dehydrogenase - ALDH) is much slower. Acetate isn't as big of a problem and tends to be cleared in step with concentrations of taurine - more on that later.
You may have heard of the Asian Glow. It refers not just to your homie that has one beer and loses it entirely, but mainly to a genetic mutation in the ALDH II enzyme that greatly reduces its activity. In short, people with this mutation build up acetaldehyde way quicker than someone without. This causes them to suffer worse hangovers from seemingly inconsequential amounts of alcohol as well as many other fun effects that you tend to only get from really hitting the sauce hard.
But wait, there's more!
Your body, being the insanely adaptive piece of genius that it is will tend to get better and better at processing alcohol - usually at the expense of other processes. Your friends that drink every weekend into oblivion probably have an easier time getting over a hangover than the guy or gal that only drinks a few times or once in a blue moon. Or put more succinctly "Hangovers are substantially more common in light-to-moderate drinkers than in heavier drinkers - possibly because the body hasn’t adapted to chronic alcohol injury. "
Here's another couple tidbits I found interesting from my research: hangover severity is inversely correlated to testosterone levels. This may be the reason that hangovers get progressively worse as we get older, as our hormone levels naturally level off and begin to drop. Oddly enough, testosterone levels will go up while drinking, but crash, with an increase in estrogen, once your BAC drops.
Acetaldehyde has been shown to be 10 to 1000x more addictive in terms of dopamine release than ethanol in multiple animal models. People aren't alcoholics, they are acetaldehydics or however that term would end up.
Here are the overall categories of effects from alcohol:
- ROS and RNS damage - inflammation, neuroinflammation, lipid peroxidation.
- The antioxidant enzyme, cofactor, and substrate depletion.
- Mitochondrial damage + dysfunction
- Endocrine system hormonal system out of wack (Lower T, Higher E)
- Neurotransmitter dysfunction (GABA, Glutamate, Dopamine, Serotonin, Acetylcholine)
- Decrease in insulin sensitivity (like diabetes) - metabolism
- Sleep Cycle disruption
- Immune system suppression
If we were to summarize this... A hangover is like having a temporary bout of anxiety, diabetes, and Alzheimers.
Major physical effects - low energy, fucked up metabolism, skin break outs, etc. tend to be caused by the exhaustion of antioxidant enzymes. Your body prioritizes using them to clear alcohol and all its metabolites that tend to react with acetaldehyde at the expense of essentially every other process that keeps you feeling good.
Major mental effects - anxiety, wanting to do stuff that gives you a quick dopamine boost like eating shit food or watching (adult) cartoons all day, having zero motivation. These are all neurochemical imbalances. The largest is GABA/Glutamate balance getting fucked up. When you drink, GABA goes up and glutamate goes down. This gives you a feeling of relaxation and ease. Arguably why you find it easier to speak to crowds of folks if you'd normally be shitting yourself nervous. During withdrawal / hangovers, this is reversed. GABA goes down, glutamate goes up. It makes you hypersensitive and anxious. It is hard to focus because everything draws your focus. Withdrawal starts the moment your BAC starts dropping. Yes, so literally after the first drink. And it will get worse as you keep going. On top of this, your normal feel-good neurotransmitters - dopamine, serotonin, acetylcholine - get depleted. So you wake up after boozing, and you're running low on happiness or whatever the chemical equivalent is. Guh. These imbalances will also make it difficult to sleep the night of drinking and even a night or two after.
For major alcoholics, the above anxiety can be absolutely crippling. And... alcohol delivers instant GABA boost which is then dopamine reinforced. Brutal. Your brain will actually start to produce less GABA as you slide into alcoholism, making it extremely difficult to get rid of this anxiety after drinking. Supplements:
I'll start with summaries on the ones I included, then give a brief summary of others that help the categories above. Feel free to shoot me a DM or leave a comment if you want a breakdown of an individual supplement that I mention but was not given a detailed description.
The primary focus of this mix is to speed up the clearance of acetaldehyde, to reinforce/protect/regenerate/enhance the antioxidant enzymes to lessen oxidative damage, and finally to get the brain's neurochemistry back into balance to lessen the chances of addictive behavior patterns and relieve the anxiety and fucked up mental state a hangovewithdrawal brings with it.
I made this formula to protect against as much harm using the fewest number of ingredients possible. At the end of this list is a summary that includes other ingredients I researched, and categorically where they could also help. Feel free to ask for summaries on them. For instance, passion flower naturally increases Testosterone and is awesome for anti-addictive behaviors. Acetyl-L-Carnitine (ALC)
- Protects antioxidant enzymes, stabilizes neurotransmission, and protects mitochondria - the power house of the cell. May help you sleep too.
Agmatine Sulfate (AS)
- Increases activity of GTX and SOD (antioxidant enzymes). Strong neuroprotective effects
- Stabilization of neurotransmission by ALC after long-term alcohol consumption may be associated with the protection of neuronal mitochondrial function
- Prevents alcohol-induced mitochondrial damage, energy depletion due to defective respiratory chain complexes, oxidative-mediated neuroinflammation, and neuronal degeneration
- Sustained the neuronal LFS and LTP synaptic transmission by preserving the integrity of neurofilaments and by maintaining dopaminergic and cholinergic neurons
- Can also potentially restore/protect acetylate histones concentrations, which are necessary for sleep and damaged by ethanol/Acetaldehyde
- Easily crosses Blood Brain Barrier (BBB)
- Helps with glutamate toxicity. Glutamate
Trimethylglycine - Betaine
- Inhibits NOS - which produces NO in the brain, a RNS.
- Attenuates glutamate induced neurotoxicity (major withdrawal symptom)
- “Agmatine is an endogenous ligand for imidazoline receptors, Imidazoline receptors modulate several actions of ethanol, its intake and the development of dependence or withdrawal syndrome. Importantly, the effects of agmatine on ethanol withdrawal induced anxiety and behavioural sensitization were mediated by imidazoline receptors.” Agamatine activates these receptors
- Normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals.
- Crosses BBB easily.
- Liver protective, accelerated clearance of acetaldehyde.
- Protects liver by restoring SAM:SAH balance, which allows certain enzymes to function properly
- Significantly reduced the (Blood Alcohol Level) BAL compared to ethanol fed rats without betaine.
- Possibly works by increasing metabolic rate to produce more NAD+ to clear ethanol/acetaldehyde
- Curcumin - Antioxidant, speeds up acetaldehyde clearance, brain protective.
- Good antioxidant, neuroprotective, liver protective, stops lipid peroxidation. Dose-dependent effect.
- Able to reverse the alcohol-induced inhibition of ADH activity and to suppress CYP2E1 activity and protein levels, which indicates that curcumin supplementation appears to promote alcohol oxidation via ADH
- reversed the alcohol-induced inhibition of the ALDH activity - promotes alcohol oxidation via ADH and also increases ALDH activity
- potently stimulates neurogenesis and therefore, it has been proposed as a therapeutic agent for treating neurodegenerative disorders and substance abuse
- acetaldehyde clearance, GABA/Glutamate neurochemistry balance.
Milk Thistle - Silymarin
- Antioxidant, antiviral, antibacterial, antiinflammatory, anticancer
- DHM improved lipid and alcohol metabolism, antioxidant capacity and lipid peroxidation on mice fed alcohol for 10 days, protecting against liver injury.
- Lowers ethanol levels in serum by increasing ADH activity.
- DHM greatly reduced EtOH consumption in an intermittent voluntary EtOH intake paradigm in rats
- Regulates the effects alcohol has on the GABA system (reverses the effects) in consumption + withdrawal
- Poor bioavailability, lipophilic, unstable in light and heat. Better to put in tandem with hovenia dulcis full spectrum flavinoid extract - then liposomal nano-encapsulation. One of the best GABA modulators available.
- oxidative stress protection, liver protection, antioxidant enzyme restoration.
- One enhanced form of silymarin binds silybin to phosphatidylcholine. Research indicates that phosphatidylcholine-bound silybin is better absorbed and produces better clinical results than other forms. 3 to 4x bioavailability. (liposome)
- Liver protective. Very potent antioxidant, increasing GSH activity and levels. Antioxidant, hepatoprotective, anti-inflammatory, immunomodulation, fat control, neuroprotective, kidney protective.
- Very low toxicity if any.
- Silymarin prevents the depletion of glutathione (GSH) induced by alcohol and other liver toxins. Even in normal people, silymarin has been shown to raise the basal GSH level in the liver by 35%.
- Oxidative stress protective, reset metabolism.
- Active compounds: Boswellic Acid + Terpene compounds - incensole (1) and incensole acetate (2) are effective in anti-inflammatory, with the latter in anti-depression.Work best in tandem vs alone.
- Boosts SOD and GSx enzymes activity in the brain, powerful antioxidant and anti-inflammatory
- Antidiabetic, boosts insulin sensitivity.
- neurotransmitter regulation - specific GABA/Glutamate
L - Theanine
- N-methylglycine may be a version of glycine that will be bioactive and can cross the BBB. Though glycine may actually be orally available.
- Glycine is a major inhibitory neurotransmitter like GABA.
- rats experiencing withdrawal from chronic alcohol consumption showed higher anxiety and sensitivity to stress compared to their alcohol-naïve counterparts. Intra-LHb injection of glycine attenuated these aberrant behaviors and reduced alcohol intake upon alcohol re-access.
- administration of glycine to alcohol-supplemented rats markedly reduced the accumulation of cholesterol, phospholipids, free fatty acids and triglycerides in the circulation, liver and brain
- Ethanol antagonizes central effects of glutamate by inhibition of the N-methyl-D-aspartate (NMDA) receptor function. The co-agonist glycine has been shown to reverse alcohol-mediated effects.
- glutamate acts as the neurotransmitter and glycine as a modulator, both co-agonists are required for full receptor activation
- Neurotransmitter regulation - specific GABA/Glutamate
- Passes freely through BBB, reduces glutamate release, increases GABA, glycine, and dopamine.- neuroprotective
- Anti-oxidant, anti-inflammatory, restoration of altered neurotransmitter levels, motor behavioral improvements.
- The inhibitory concentration of L-theanine was found to be 80 to 30,000- fold less than that of L-glutamic acid. L-theanine is capable of binding to all the three glutamate receptors subtypes and cause favorable down-regulation of glutamate excitotoxicity
- Has been recommended as a sleep aid because of its anti-anxiety effects.
- L-theanine administration at daily doses of 200–400 mg appears to confer anxiolytic and stress-reducing effects. Acute effects of L-theanine are observed few hours after its intake, and its chronic effects also appear to be positive
- Reducing oxidative damage and regulating/protecting proper neurochemistry.
Taurine - N-Acetyl-Taurine (NAT)
- Alcohol-induced oxidative stress was inhibited by NAC supplementation in multiple studies.
- Antioxidant, antiinflammatory. Prevents withdrawal stress. Anti-addictive
- As a glutamate-modulating agent, NAC can quickly stabilize a hyperactive glutamate system in a critical timing for withdrawal and relapse
- Oral supplementation appears to be of low bioavailability (< 10%) such that oral administration of 600–1200 mg NAC per day resulted in only 16 and 35 μM plasma NAC, respectively. There were complications when NAC was administreted intraveneously.
- N-acetylcysteine, an amino acid derivative, helps to restore the levels of phospholipids to near normal during ethanol-induced toxicity
- Ameliorates negative neuroadaptive changes produced by alcohol, as well as alcohol induced behavioral sensitization, anxiety-like behavior and alcohol withdrawal signs in preclinical models
- Alcohol withdrawal increases leptin, NAC reversed this
- Previous work demonstrating the neuroprotective effects of NAC on oxidative stress and inflammation in the brain underlie the hypothesis of the current study. NAC is an indirect precursor for GSH by elevating the levels of cysteine which leads to GSH synthesis. It is well demonstrated that NAC is a GSH enhancing agent (from GCG study)
- ***One study found that NAC given after alcohol intoxication worsens effects. I mention this earlier about when to take this formulation.
- clearing acetate and speeding up clearance of acetaldehyde.
Nicotinamide Mononucleotide (NMN)
- Taurine is involved in alcohol metabolism to form NAT. An increase in taurine could increase EtOH metabolism
- Ethanol -> acetate. Taurine clears acetate. Too much acetate is hyperacetatemia.
- Hyperacetatemia has been associated with the development of dyslipoproteinemia and atherosclerosis, especially in some hemodialysis patients (66), and has also been recently implicated as a main cause of alcohol hangover headache
- Taurine’s level can partially reflect the status of sulfur-containing amino acids in vivo. The protective effects of taurine against the ethanol-induced toxicities, such as hepatic steatosis and lipid peroxidation, have been revealed in several studies on taurine supplementation
- Acetate increases adenosine in many tissues, including the brain - [49,50]. The adenosine receptor antagonist, caffeine, administered after ethanol, blocked the nociceptive behaviors associated with ethanol. This suggests that adenosine contributes to ethanol induced hypersensitivity. Taurine clears acetate, so less adenosine.
- Nicotinamide Riboside and Ubiquinone are very similar - speeding up metabolism of acetaldehyde and regenerating antioxidant enzymes.
- Treatment with NMN prominently rescued the ethanol-induced reduction in the NAD+/NADH ratio
- Ubiquinone speeds up the metabolism of alcohol and acetaldehyde by increasing NAD+ availability.
- NR, NMN, and Ubiquinol are all NAD+ precursors
- NR has been identified as an NAD+ precursor, existing in foods, without side effects of flushing . Boosting NAD+ concentrations and NAD+ dependent enzymes can be therapeutic in certain metabolic disorders, such as obesity, NAFLD and T2D, even hepatocellular carcinoma
- NMN also increased NAD+ levels, which could be a useful intervention related to metabolic disorders, but it isn’t found in dietary constituents
- restoring neurotransmitters
Notes on Supplements:
- Tyrosine is the main precursor to catecholamines (dopamine, norepinephrine, epinephrine)
- Tyrosine hydroxylase (TH) is the rate-limiting enzyme responsible for dopamine synthesis, whereas monoamine oxidase is the enzyme responsible for the breakdown of dopamine into DOPAC
- A recent study found that alcohol increases the activity of TH without altering the activity of monoamine oxidase
Plant extracts tend to have a major problem. Bioavailability. For example, milk thistle is less than 1% bioavailable. Recently, advances have been made to increase bioavailability with encapsulation methods - most notably the phytosome and liposomal encapsulation techniques - or including other ingredients that increase bioavailability - like black pepper (bioperine) for curcumin.
In my ingredients, I mention betacyclodextrin and phytosomes. These are two encapsulation methods that increase bioavailability about 5 to 10x. They also make the extracts more dissolvable in water. Indena is THE major seller of phytosomal complexes - they got patents - and they sell to multiple retailers. If you type phytosome curcumin in Amazon, you'll find them. Another source is botany.bio
Everything else mentioned can be found on Amazon in bulk powder with great quality and on the cheap. Summary of Effects and Other Supplements Researched :
ROS and RNS damage - inflammation, neuroinflammation, lipid peroxidation.
- Agmatine Sulfate, Alpha Lipoic Acid, Betaine, Boswellia, Beta-caryophyllene, Curcumin, Dihydromyricetin, Epigallocatechin Gallate, Gingko Biloba, Ginseng + Sea Buckthorn, Glycine, Honokiol + Magnolol + Ginger, L - citrulline, L - Theanine, Milk Thistle, N-Acetyl-Cysteine, Oleoylethanolamide, Resveratrol, Spirulina, GCG
Antioxidant enzyme, cofactor, and substrate depletion.
- Acetyl-L-Carnitine, Alpha Lipoic Acid, Ashwaganda, Curcumin, Magnesium, Manganese, Zinc, Milk Thistle, N-Acetyl-Cysteine, N-Acetyl-Taurine, GCG
Mitochondrial damage + dysfunction
- Acetyl-L-Carnitine, Alpha Lipoic Acid, Nicotinamide Riboside
Endocrine system hormonal systems out of whack
- Agmatine Sulfate, Ginseng + Sea Buckthorn, Passion Flower
Neurotransmitter dysfunction (GABA, Glutamate, Dopamine, Serotonin, Acetylcholine)
- Agmatine Sulfate, Ashwaganda, Curcumin, Dihydromyricetin, Honokiol + Magnolol + Ginger, Levo - tetrahydropalmatine, L - Theanine, Melatonin, N-Acetyl-Cysteine, Oleoylethanolamide, Passion Flower, Resveratrol, Tyrosine
Decrease in insulin sensitivity (like diabetes) - metabolism
- Betaine, Boswellia, Gingko Biloba, Glycine, Milk Thistle, N-Acetyl-Taurine, Nicotinamide Riboside, Oleoylethanolamide, Resveratrol, Spirulina, GCG
Sleep Cycle disruption - histone acetylation disruption, circadian rhythm.
- Acetyl-L-Carnitine, Honokiol + Magnolol + Ginger, L - Theanine, Melatonin, Passion Flower
Microbiome damage About Me and Whatever:
During this awesome pandemic, I found myself unemployed after selling a previous company. It was at this time that my father started just randomly blacking out when he got up too quickly. To make a long story short, he went to a doc - and doc told him you need to stop drinking. Soon after my mom caught him sneaking swigs in the garage. He finally admitted he'd been an alcoholic for 30 years, basically sneaking off to drink without anybody knowing. Great.
With time on my hands and a bit of anger, I decided to jump back onto this project. I didn't want other people to end up like my dad. From my research, I quickly found that hangovers are a form of withdrawal. The primary cause of alcoholism is from the GABA/Glutamate imbalance during withdrawal that makes it oh so easy to drink more and more.
I blasted through about 400 or so research papers to dig into natural supplements available to remedy as many of the effects of alcohol I could find. I presented my findings to my dad, and he was pretty blown away. Not because it was a magical cure, but because the main thesis was something he had already heard. As it turns out, about a week before I shared all my research and the initial formulation of 40 something supplements, he had found a new age clinic that had repurposed GABA regulating pharmaceuticals to combat alcoholism - with astonishing success.
My dad had been running through various programs over these past months with very little to show for it. This pharma treatment that specifically targeted the GABA/Glutamate balance has been working for him. As of today, he's been sober for about 3.5 months.
Alcoholism is a sliding scale. It's not a binary - alcoholic, non-alcoholic thing. And it is specific to each person. It just seems to me, at least from my experience seeing other friends fall off a cliff in this shit, is that it starts slow and can accelerate at such a slow pace that it doesn't even seem like anything has changed. Then you hit an inflection point, maybe caused by something as mundane as losing a girlfriend or job (or being isolated for 6 months in quarantine) and that process speeds up to where you lose control.
So when I've been asked, "won't stopping a hangover make people just drink more." This is a major part of my answer. I also believe that we should take all measures to protect our health - body and mind - if we decide to take substances that we know are harmful. Everyone knows alcohol is essentially poison, so why not make it better?
Of course, this formulation is not for alcoholics. If you have a serious problem, go get help.
Cheers. u/stck123 u/DDRFlashGordon u/relaxed_1 u/BraveSirrrRobin u/pompino u/sillykumquat- u/nejonehas u/ShivasLimb u/Dal567
submitted by BurkeAbroad
to Supplements [link] [comments]
2021.07.24 18:53 Jgarr86 Breathing and Socialism
It should come as no surprise to anyone here, but we've all been breathing air under the Capitalist MoP for a few hundred years now. Can anyone shine some light on how breathing air into/out from your lungs might work under Socialism? It's not like we can cut up air into equal chunks, so it seems like something that should be left up to the free market.
submitted by Jgarr86 to Socialism_101 [link] [comments]
2021.07.24 18:53 lunastrrange Anyone else feel like they woke up in someone else's life when they started treatment?
Everything from before feels like a dream/nightmare, or like past lives or something I didn't participate in. I just feel so different now, finally myself again. The medication made things much clearer to me and I just can shake this feeling that I don't belong here. Like I'm a different person. I still have episodes though it's not like I'm 100%, I just see things so differently now and I don't think I would have done anything the same if I had gotten treatment 15 years ago when I was a teenager.
I guess I'm just really confused and lost right now, but I also feel like I'm coming home to myself. This shit is so overwhelming and I often wish I could go back to being in my own crazy little oblivious world.
Just needed to get that out, it's taken over my brain lately. Thanks for reading :)
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2021.07.24 18:53 FrontpageWatch2020 [#788|+516|6] A Nintendo Classic. [r/nintendo]
submitted by FrontpageWatch2020 to longtail [link] [comments]